Publications


2017

Atanasov J, Weigand JE, Suess B
Design and implementation of a synthetic pre-miR switch for controlling miRNA biogenesis in mammals. submitted

Schneider C, Bronstein L, Diemer J, Koeppl H, Suess B
ROC'n'Ribo: Characterizing a riboswitching expression system by modeling single-cell data. in revision

Ohuchi S, Suess B
Inhibitory RNA aptamer against lambda cI repressor shows the transcriptional activator activity in vivo. in revision

Saul MJ, Groher F, Hegewald AB, Müller-McNicoll M, Marschalek R, Suess B, Steinhilber D
TGFβ/Smad signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation. submitted

Steinert H, Sochor F, ..., Rudolph MM, ..., Suess B, Fürtig B, Wöhnert J, Schwalbe H,
Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation. in revision

Kim YB, Wacker A, von Laer K, Rogov V, Suess B, Schwalbe H
Ligand binding to 2'-deoxyguanosine sensing riboswitch in metabolic context. Nucleic Acids Res ahead of print

Toulmé J-J, Giangrande PH, Mayer G, Suess B, Ducongé F, Sullenger B, De Franciscis V, Darfeuille F and Peyrin E
Aptamers in Bordeaux, 24-25 June 2016. Pharmaceuticals (Basel) 10(1). pii: E14. doi: 10.3390/ph10010014.

Kemmerer K, Weigand JE and Suess B
Synthetic Splicing and Alternative Splicing - Impact on Gene Design. WILEY BIOTECHNOLOGY SERIE in revision


2016

Saul MJ, Stein S, Grez M, Jakobsson PJ, Steinhilber D, Suess B.
UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance. Sci Rep 2016 Aug 30;6:31995. doi: 10.1038/srep31995

Groher F, Suess B
In vitro selection of antibiotic-binding aptamers. Methods 106:42-50. doi: 10.1016/j.ymeth.2016.05.008. Epub 2016 May 17

Sommer MO, Suess B
RIBOSWITCHES. (Meta-)genome mining for new ribo-regulators. Science 352(6282):144-5. doi: 10.1126/science.aaf6189.

Schneider C, Suess B
Identification of RNA aptamers with riboswitching properties. Methods 97:44-50. doi: 10.1016/j.ymeth.2015.12.001. Epub 2015 Dec 7.

Duchardt-Ferner E, Gottstein-Schmidt SR, Weigand JE, Ohlenschläger O, Wurm J-P, Hammann C, Suess B and Wöhnert J
What a Difference an OH Makes: Conformational Dynamics as the Basis for Ligand Specificity of the Neomycin Sensing Riboswitch. Angew Chem Int Ed Engl. 55(4):1527-30. doi: 10.1002/anie.201507365. Epub 2015 Dec 11

Vogel M, Suess B
Label-Free Determination of the Dissociation Constant of Small Molecule-Aptamer Interaction by Isothermal Titration Calorimetry. Methods Mol Biol 1380:113-25. doi: 10.1007/978-1-4939-3197-2_9.


2015

Pedrolli DB, Kühm C, Sévin DC, Vockenhuber MP, Sauer U, Suess B and Mack M
A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis. Proc Natl Acad Sci U S A 112(45):14054-9. doi: 10.1073/pnas.1515024112. Epub 2015 Oct 22.

Wenk P, Kaushik M, Richter D, Vogel M, Suess B and Corzilius B
Dynamic Nuclear Polarization of Nucleic Acid with Endogenously Bound Manganese JNMR 63(1):97-109. doi: 10.1007/s10858-015-9972-1. Epub 2015 Jul 29

Rohde J-H, Weigand JE, Suess B and Dimmeler S
A universal aptamer chimera for the delivery of functional microRNA-126. Nucleic Acid Ther 25(3):141-51. doi: 10.1089/nat.2014.0501

Vockenhuber MP, Heueis N and Suess B
Identification of metE as a second target 1 of the sRNA scr5239 in Streptomyces coelicolor. PlosOne 10(3):e0120147. doi: 10.1371/journal.pone.0120147

Berens C, Groher F and Suess B
RNA aptamers as genetic control devices. Biotechnology Journal 10(2):246-57. doi: 10.1002/biot.201300498

Özçoban C, Halbritter T, Steinwand S, Herzig LM, Kohl-Landgraf J, Askari N, Groher F, Fürtig B, Richter C, Schwalbe H, Suess B, Wachtveitl J and Heckel A
Water-Soluble Py-BIPS Spiropyrans as Photoswitches for Biological Applications. Org Lett 17(6):1517-20. doi: 10.1021/acs.orglett.5b00397

Rudolph MM, Vockenhuber MP and Suess B Access the recommendation on F1000Prime
Conditional Control of Gene Expression by Synthetic Riboswitches in Streptomyces coelicolor Methods Enzymol, 550:283-99. doi: 10.1016/bs.mie.2014.10.036.

Busch S, Auth W, Scholl F, Huenecke S, Koehl U, Suess B and Steinhilber D
5-Lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p. Journal of Immunology 94(4):1646-53. doi: 10.4049/jimmunol.1402163. Epub 2015 Jan 14


2014

Beilstein K, Wittmann A, Grez M and Suess B
Conditional control of mammalian gene expression by tetracycline-dependent hammerhead ribozymes. ACS Synth Biol 4(5):526-34. doi: 10.1021/sb500270h

Reuss AJ, Vogel M, Weigand JE, Suess B and Wachtveitl J.
Tetracycline Determines the Conformation of its Aptamer at Physiological Magnesium Concentrations. Biophysical Journal 107(12):2953-2962. doi: 10.1016/j.bpj.2014.11.001

Berens C, Suess B
Riboswitch engineering - making the all-important second and third steps. Curr Opin Biotechnol 31C:10-15. doi: 10.1016/j.copbio.2014.07.014.

Weigand JE, Gottstein-Schmidtke SR, Demolli S, Groher F, Duchardt-Ferner E, Wöhnert J and Suess B
Sequence elements distal to the ligand binding pocket tune the efficiency of a synthetic riboswitch. ChemBioChem 15(11):1627-37. doi: 10.1002/cbic.201402067.

Gottstein-Schmidtke SR, Duchardt-Ferner E, Groher F, Weigand JE, Gottstein D, Suess B and Wöhnert J
Building a stable U-turn with a protonated cytidine. RNA 20(8):1163-72. doi: 10.1261/rna.043083.113.

Groher F, Suess B.
Synthetic riboswitches - A tool comes of age. Biochim Biophys Acta pii: S1874-9399(14)00111-4. doi: 10.1016/j.bbagrm.2014.05.005.

Heueis N, Vockenhuber MP, Suess B.
Small non-coding RNAs in streptomycetes. RNA Biol 11(5).

Demolli S, Geist MM, Weigand JE, Matschiavelli N, Suess B, Rother M.
Development of β-Lactamase as a Tool for Monitoring Conditional Gene Expression by a Tetracycline-Riboswitch in Methanosarcina acetivorans.Archaea 2014:725610. doi: 10.1155/2014/725610.

Ochs MJ, Suess B and Steinhilber D
5-Lipoxygenase mRNA and protein isoforms. Basic Clin Pharmacol Toxicol 114(1):78-82. doi: 10.1111/bcpt.12115.

Ochs MJ, Steinhilber D, Suess B
MicroRNAs-novel therapeutic targets of eicosanoid signalling. Basic Clin Pharmacol Toxicol 114(1):92-6. doi: 10.1111/bcpt.12116.


2013

Meitert J, Aram R, Wiesemann K, Weigand JE and Suess B
Monitoring the expression level of coding and non-coding RNAs using a TetR inducing aptamer tag. Bioorganic & Medical Chemistry 21(20):6233-8. doi: 10.1016/j.bmc.2013.07.035.

Heinrich EM, Wagner J, Krüger M, John D, Uchida S, Weigand JE, Suess B and Dimmeler S.
Regulation of miR-17-92a cluster processing by microRNA binding protein SND1. FEBS letters 587(15):2405-11. doi: 10.1016/j.febslet.2013.06.008

Rudolph MM, Vockenhuber MP and Suess B.
Synthetic riboswitches for the conditional control of gene expression in
Streptomyces coelicolor. Microbiology 159(Pt 7):1416-22. doi: 10.1099/mic.0.067322-0.

Dovizio M, Maier T, Alberti S, Di Francesco L, Marcantoni E, Münch G, John C, Suess B, Sgambato A, Steinhilber D and Patrignani P.
Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells. Molecular Pharmacology 84(1):25-40. doi: 10.1124/mol.113.084988.

Ochs MJ, Ossipova E, Oliynyk G, Steinhilber D, Suess B and Jakobsson PJ
Mass spectrometry based proteomics identifies UPF1 as a critical gene expression regulator in Mono Mac 6 cells. J Proteomics Res 12(6):2622-9. doi: 10.1021/pr301193f.


2012

Langner JS, Fuchs NV, Hoffmann J, Wittmann A, Brutschy B, Löwer R and Suess B.
Biochemical analysis of the complex between the tetrameric export adapter protein Rec of HERV-K/HML-2 and the responsive RNA element RcRE pck30. J Virol 2012 Sep;86(17):9079-87. doi: 10.1128/JVI.00121-12.

Wittmann A, Suess B.
Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators. FEBS letters 2012 Jul 16;586(15):2076-83. doi: 10.1016/j.febslet.2012.02.038.

Ochs MJ, Pufahl L, Sorg B, Grez M, Suess B and Steinhilber D
Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay. PLoS One 2012;7(2):e31363. Epub 2012 Feb 21.

Suess B, Entian KD, Kötter P, Weigand J.
Aptamer-regulated expression of essential genes in yeast. Methods Mol Biol 2012;824:381-91. doi: 10.1007/978-1-61779-433-9_20.

Weigand JE, Wittmann A, Suess B.
RNA-based networks: Using RNA aptamers and ribozymes as synthetic genetic devices. Methods Mol Biol 2012;813:157-68. doi: 10.1007/978-1-61779-412-4_9.

Vockenhuber MP, Suess B.
Streptomyces coelicolor sRNA scr5239 inhibits agarase expression by direct base pairing to dagA coding region. Microbiology 2012 Feb;158(Pt 2):424-35. doi: 10.1099/mic.0.054205-0.

Förster U, Weigand JE, Trojanowski P, Suess B, Wachtveitl J.
Conformational dynamics of the tetracycline-binding aptamer. Nucleic Acid Research 2012 Feb;40(4):1807-17. doi: 10.1093/nar/gkr835.


2011

Steber M, Arora A, Hofmann J, Brutschy B, Suess B.
Mechanistic basis for aptamer-based induction of TetR. Chem Bio Chem 2011 Nov 25;12(17):2608-14. doi: 10.1002/cbic.201100503. Epub 2011 Oct 21.

Ochs MJ, Steinhilber D, Suess B.
MicroRNA involved in inflammation: Control of eicosanoid pathway. Front Pharmacol 2011;2:39. Epub 2011 Jul 21.

Hammann C, Hartmann RK, Helm M, Klostermeier D, Marchfelder A, Suess B, Vörtler S.
Regulatory RNAs and beyond. EMBO reports 2011 Jul 15;12(8):751-3. doi: 10.1038/embor.2011.150.

Wittmann A, Suess B.
Selection of tetracycline inducible self-cleaving ribozymes as synthetic devices for gene regulation in yeast. Molecular Biosystems 2011 May 20, 7 (8), 2419 - 2427

Arora A, Suess B.
An RNA G-quadruplex in the 3' UTR of the proto-oncogene PIM1 represses translation. RNA Biology 2011 Sep 1;8(5).

Vockenhuber MP, Sharma C, Statt MG, Schmidt D, Xu Z, Dietrich S, Liesegang H, Mathews D, Suess B.
Deep sequencing-based identification of small non-coding RNAs in Streptomyces coelicolor. RNA Biology 2011 May 1;8(3).

Weigand JE, Schmidtke SR, Will T, Duchardt-Ferner E, Wöhnert J, Suess B.
Mechanistic insights into an engineered riboswitch: a switching element which confers riboswitch activity. Nucleic Acid Research 2011 Apr 1;39(8):3363-72. Epub 2010 Dec 11.

Wunnicke D, Strohbach D, Weigand JE, Appel B, Feresin E, Suess B, Müller S, Steinhoff HJ.
Ligand-induced conformational capture of a synthetic tetracycline riboswitch revealed by pulse EPR. RNA 2011 Jan;17(1):182-8. Epub 2010 Nov 19.


2010

Duchardt-Ferner E, Weigand JE, Ohlenschläger O, Schmidtke SR, Suess B, Wöhnert J.
Highly modular structure and ligand binding by conformational capture in a minimalistic riboswitch. Angew Chem Int Ed Engl 2010 Aug 16;49(35):6216-9

Schmidtke SR, Duchardt-Ferner E, Weigand JE, Suess B, Wöhnert J.
NMR resonance assignments of an engineered neomycin-sensing riboswitch RNA bound to ribostamycin and tobramycin. Biomol NMR Assign 2010 Mar 21. [Epub ahead of print]

Krstic I, Frolow O, Sezer D, Endeward B, Weigand JE, Suess B, Engels JW, Prisner FT.
PELDOR spectroscopy reveals preorganization of the neomycin-responsive riboswitch tertiary structure. J Am Chem Soc 2010 Feb 10;132(5):1454-5.

Suess B.
Riboswitches: New aspects of an old story. Guest editor: RNA Biology Special focus Riboswitches. RNA Biology 7(1), 64-65.


2009

Weigand JE, Suess B.
Aptamers and Riboswitches: Perspectives in Biotechnology. Applied Microbiology and Biotechnology 2009 Nov;85(2):229-36. Epub 2009 Sep 16.

Kötter P, Weigand JE, Meier B, Entian KD, Suess B.
A fast and efficient translational control system for conditional expression of yeast genes. Nucleic Acids Research 2009 Jul 10. Epub ahead of print

Weigand JE, Suess B.
Aptamers as artificial gene regulation elements. Methods Mol Biol 2009;535:201-8.

Hunsicker A, Steber M, Mayer G, Klotzsche M, Hillen W, Berens C, Suess B.
An aptamer that induces transcription. Chem Biol 2009 Feb 27;16(2):173-80.

Hering O, Brenneis M, Beer J, Suess B, Soppa J.
A novel mechanism for translation initiation operates in haloarchaea. Mol Microbiol 2009 Mar;71(6):1451-63.


2008

Weigand JE, Sanchez M, Gunnesch EB, Zeiher S, Schroeder R, Suess B.
Screening for engineered neomycin riboswitches that control translation initiation. RNA 14, 89-97.

Suess B, Weigand JE.
Engineered riboswitches: Overview, problems and trends. RNA Biology 5, 24-29.

Suess B.
Nucleic Acids from A to Z. S. Müller, ed. Wiley-VCH 2008 , in press.


2007

Weigand JE, Suess B.
Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast. Nucleic Acid Research 35, 4179-4185.

Weigand JE, Suess B.
A designed RNA shuts down transcription. Chem Biol 14, 9-11.


2006

Muller M, Weigand JE, Weichenrieder O, Suess B.
Thermodynamic characterization of an engineered tetracycline-binding riboswitch.Nucleic Acids Research 34, 2607-2617.

Suess B.
Trendbericht: RNA-Schalter. Nachrichten aus der Chemie 54, 273-275.

Suess B.
RNA-Schalter - neuartige Regulatoren der Genexpression.Naturwissenschaftliche Rundschau 698, 423-428.

Bauer G, Suess B.
Engineered riboswitches as novel tools in molecular biology. J Biotechnol 124, 4-11.


2005

Hanson S, Bauer G, Fink B, Suess B
Molecular analysis of a synthetic tetracycline-binding riboswitch. RNA 11,503-511.

Suess B.
Engineered riboswitches control gene expression by small molecules. Biochem Soc Trans 33, 474-476.

Berens C, Suess B.
Synthetic riboregulators - an alternative means to control gene expression. Gene Ther Mol Biol 9, 417-422.


2004-1998

Suess B, Fink B, Berens C, Stentz R and Hillen W (2004)
A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo. Nucleic Acid Research 32(4),1610-1614.

Hanson S, Berthelot K, Fink B, McCarthy JE, Suess B. (2003).
Tetracycline-aptamer-mediated translational regulation in yeast. Mol Microbiol 49, 1627-1637.

Suess B*, Hanson S, Berens C, Fink B, Schroeder R, Hillen W. (2003).
Conditional gene expression by controlling translation with tetracycline-binding aptamers. Nucleic Acids Research 31, 1853-1858. (* corresponding author)

Steinhoff HJ, Suess B. (2003).
Molecular mechanisms of gene regulation studied by site-directed spin labeling. Methods 29, 188-195.

Tiebel B, Garke K, Hillen W (2000)
Observing concomitant conformational and activity changes of Tet repressor in vivo. Nature Structural Biology 7, 479-481.

Tiebel B, Radzwill N, Aung-Hilbrich LM, Helbl V, Steinhoff HJ and Hillen W (1999)
Domain motions accompanying Tet repressor induction defined by changes of interspin distances at selectively labelled sites. J Mol Biol 290, 229-240.

Tiebel B, Aung-Hilbrich LM, Schnappinger D and Hillen W (1998)
Conformational changes necessary for gene regulation by Tet repressor assayed by reversible disulfide bond formation. EMBO J17, 5112-5119.

Helbl V, Tiebel B and Hillen W (1998)
Stepwise selection of TetR variants recognizing tet Operator 6C with high affinity and specificity. J Mol Biol 276, 319-324.